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 >>  . C 05.13.00
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Aim. To investigate the content of pepsin in saliva of patients with GERD.

Methods. There was comprehensively examined 18 patients with GERD. all the patients

were surveyed (to identify typical complaints) and performed endoscopic examination

of the upper gastrointestinal tract for GERD verification. The saliva samples were

analyzed in all patients. Pepsin determination was carried out according to V.P.Tang.

Normal values of human pepsin in saliva was found in 22 healthy volunteers.

Results. It was established that the average value of ranked number of pepsin in saliva of healthy volunteers group was 0,021 mg/ml, among those with nonerosive GERD corresponding value was 0,032 mg/ml, in patients with erosive form of the disease the level of pepsin in saliva was 0.087 mg/ml. It was shown that the determination of the content of pepsin in saliva can be used as a simple non-invasive diagnostic marker of GERD with 85,7% specificity and 61,1% sensitivity.

Key words: gastroesophageal reflux disease, saliva, pepsin.

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1. ' 2020 . 1 2011 N 454. : ˳ :

http://search.ligazakon.ua/l_doc2.nsf/link1/MOZ13923.html

2. Keshavarzian A.I. Clinical implications of liver biopsy findingsin collagenvascular disorders / A.I. Keshavarzian, R. Rentsch, H.J. Hodgson // J.Clin.

Gastroenterol. - 1993. - 17 (3). P. 219-26.

3. Singh G. Can livertest abnormalities in patients with rheumatoid arthritis be predicted by clinical symptoms?/ G. Singh, J.F. Fries // J. Rheumatol. - 1992. P.1158-9. PMID: 1512780 [Pub Med - indexedfor MEDLINE]

4. Courtney Taylor. What is the difference between type i and type iierrors?

: http://statistics.about.com/od/inferential-statistics/a/type-i-andtype-ii-errors.htm.

5. Aletaha D. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology / European League Against Rheumatism collaborative initiative / D.

Aletaha, T. Neogi, A.J. Silmanetal. // Ann. Rheum. Dis. - 2010.-69.- P.15801588.

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